A number of people, including women and children, were killed in Damascus’ southern town of Kanaker on Wednesday, Syrian state television reported.
The vehicle was parked near the Amari mosque, said the report.
The Britain-based Syrian Observatory for Human Rights quoted activists as saying that seven people were killed in the blast.
Although Kanaker is controlled by forces loyal to Syrian President Bashar al-Assad, rebels surround the area. There has been intense clashes in the province around Damascus in the past two years since the uprising against Assad started.
At least 90,000 people have been killed in the two-year conflict, according to the United Nations.
Assad’s forces, spurred on by a series of recent battleground victories, have staved off rebel advances near Damascus and further south of the capital, in areas near the Jordanian border. Insurgents have used car bombs to target areas they are not able to push into with ground forces.