A suicide bomber detonated an explosives-rigged vehicle near a checkpoint north of Baghdad on Monday, killing 10 people, officials said.
The blast at the entrance to the town of Khales also wounded 36 people, according to Hassan al-Mamuri, the local official responsible for the area, and Faris al-Azzawi, the spokesman for the Diyala province health department.
There was no immediate claim of responsibility for the attack, but ISIS carries out frequent suicide bombings in Iraq.
The blast came a day after a suicide bombing claimed by ISIS killed at least 15 people in Baghdad's Kadhimiyah neighborhood.
ISIS overran large areas north and west of Baghdad in 2014, but Iraqi forces have since regained significant ground and are conducting operations to set the stage for the battle to recapture Mosul, the last ISIS-held city in the country.
The militants have responded to the battlefield setbacks by striking civilians, and experts have warned there may be more such attacks as the militants continue to lose ground.