ISIS has moved its headquarters from Syria's Raqqa to Deir Ezzour, according to a report published by Fox News this week.
The move is seen as an indicator of a potential breakdown within the terrorist organization.
Fox News quoted sources in the Pentagon as saying that ISIS had reinforced their presence in Deir Ezzour two months ago.
The sources also said that hundreds of ISIS officials and administrators left Raqqa to the area of al-Mayadeen, which lies 50 kilometers southeast of Ezzour.
However, the relocation did not protect ISIS leaders from evading the Americans.
On Saturday, Washington revealed the implementation of a military operation in the same region, which resulted in the death of the senior leader of the organization Abdul Rahman al-Uzbek, who was close to ISIS leader Abu Bakr al-Baghdadi.