Combining AstraZeneca’s COVID-19 vaccine with a second dose from either Pfizer-BioNTech or Moderna’s jab provides “good protection,” Denmark’s State Serum Institute said on Monday.
A growing number of countries are looking at switching to different COVID-19 vaccines for second doses, a measure particularly necessary in Denmark after health authorities discontinued inoculations with AstraZeneca’s vaccine in April over rare side-effect concerns.
More than 144,000 Danes, mostly frontline personnel in the health sector and the elderly, received their first jab with AstraZeneca’s vaccine but were subsequently vaccinated with either Pfizer-BioNTech or Moderna’s shots.
“The study shows that fourteen days after a combined vaccination program, the risk of infection with SARS-CoV-2 is reduced by 88 percent compared to unvaccinated individuals,” the State Serum Institute (SSI) said.
That is a “high efficacy,” SSI added, comparable to the 90 percent efficacy rate of two doses from Pfizer-BioNTech’s vaccine, confirmed in a different Danish study.
The study, published last week, covered a span of more than five months between February and June this year, a period in which the Alpha-variant of the coronavirus was predominant.
It could not conclude whether the same protection applied to the Delta-variant, which is now the most widespread in Denmark.
It also provided no efficacy data on COVID-19 related deaths or hospitalizations, since none took place following the combined vaccination program.
Explainer: The difference between COVID-19 mRNA and Adenovirus-vector vaccinesWhen COVID-19 invades our bodies, the virus tries to overcome the immune system. It attacks and multiplies in huge numbers readying itself for the ... Coronavirus
Benefits of mRNA COVID-19 vaccines outweigh rare heart risks: WHOThe benefits of mRNA COVID-19 vaccines outweigh the very small risk they might cause heart inflammation, as the jabs reduce hospitalisations and ... Coronavirus
Risk of blood clots in Pfizer COVID-19 vaccine as likely as AstraZeneca jab: StudyThe Pfizer-BioNTech COVID-19 vaccine is just as likely as the AstraZeneca jab to cause blood clots, a Lancet study has found. For more coronavirus ... Coronavirus
Mixing AstraZeneca, Pfizer COVID-19 vaccines boost antibody level, study findsA mixed vaccination of first AstraZeneca and then a Pfizer COVID-19 shot boosted neutralizing antibody levels by six times compared with two ... Coronavirus