Like two US presidents before him, Donald Trump could temporarily hand over power to his vice president should he become incapacitated, for example while undergoing a medical procedure as treatment for the coronavirus.
Karen and I send our love and prayers to our dear friends President @realDonaldTrump and @FLOTUS Melania Trump. We join millions across America praying for their full and swift recovery. God bless you President Trump & our wonderful First Lady Melania.— Mike Pence (@Mike_Pence) October 2, 2020
The 25th Amendment's Section 4 also offers a path to stripping a president of power if, for instance, his Cabinet believes he has become incapacitated, but this has never been invoked.